Warning: Creating default object from empty value in /hotel/apache/htdocs/berzelii/modules/CustomContent/CustomContent.module.php on line 238 Berzelii - Publications from Alzheimer's research, Chronic Pain research, Explorative research, Technology development at Uppsala Berzelii Centre

Publications from Uppsala Berzelii Technology Centre for Neurodiagnostics


Thematic research area Alzheimer's Disease

2012

[Back]

2011

Näsström T, Gonçalves S, Sahlin C, Nordström E, Screpanti Sundquist V, Lannfelt L, Bergström J, Outeiro TF, Ingelsson M. Antibodies against Alpha-Synuclein Reduce Oligomerization in Living Cells. PLoS One. 2011;6(10):e27230.
Welander H, Bontha SV, Näsström T, Karlsson M, Nikolajeff F, Danzer K, Kostka M, Kalimo H, Lannfelt L, Ingelsson M, Bergström J. Gelsolin co-occurs with Lewy bodies in vivo and accelerates α-synuclein aggregation in vitro. Biochem Biophys Res Commun. 2011 Aug 19;412(1):32-8.
Näsström T, Fagerqvist T, Barbu M, Karlsson M, Nikolajeff F, Kasrayan A, Ekberg M, Lannfelt L, Ingelsson M, Bergström J. The lipid peroxidation products 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote the formation of α-synuclein oligomers with distinct biochemical, morphological, and functional properties. Free Radic Biol Med. 2011 Feb 1;50(3):428-37.
Sehlin D, Hedlund M, Lord A, Englund H, Gellerfors P, Paulie S, Lannfelt L, Pettersson FE (2011) Heavy chain CDRs determine conformation selectivity of anti-Aβ antibodies Neurodegener Dis. 2011;8(3):117-23.
[Back]

2010

Kamali-Moghaddam M, Pettersson FE, Wu D, Englund H, Darmanis S, Lord A, Tavoosidana G, Sehlin D, Gustafsdottir S, Nilsson LN, Lannfelt L, Landegren U. Sensitive detection of Aβ protofibrils by proximity ligation--relevance for Alzheimer's disease. BMC Neurosci. 2010 Oct 5;11:124.
Sandberg A, Luheshi LM, Söllvander S, Pereira de Barros T, Macao B, Knowles TP, Biverstål H, Lendel C, Ekholm-Petterson F, Dubnovitsky A, Lannfelt L, Dobson CM, Härd T. Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering. Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15595-600.
Sehlin D, Hedlund M, Lord A, Englund H, Gellerfors P, Paulie S, Lannfelt L, Pettersson FE. Heavy-Chain Complementarity-Determining Regions Determine Conformation Selectivity of Anti-Abeta Antibodies. Neurodegener Dis. 2010 Aug 13.
Sehlin D, Söllvander S, Paulie S, Brundin R, Ingelsson M, Lannfelt L, Pettersson FE, Englund H. Interference from Heterophilic Antibodies in Amyloid-beta Oligomer ELISAs. J Alzheimers Dis. 2010 Aug 6.
[Back]

2009

Ingelsson M, Basun H, Pettersson FE, Kilander L, Nilsson LN, Lannfelt L. Rare mutations aim toward future treatment. Lakartidningen 2009; 106: 1396-400.
Sundelöf J, Larsson A, Rönnemaa E, Degerman-Gunnarsson M, Helmersson J, Basun H, Kilander L, Lannfelt L, Basu S. Systemic Tocopherols and F2-isoprostanes and the Risk of Alzheimer´s disease, Dementia and Mild Cognitive Impairment: A Prospective Population-Based Study. J Alzheimers Dis. 2009;18(1):71-8.
Englund H, Degerman Gunnarsson M, Brundin RM, Hedlund M, Kilander L, Lannfelt L, Pettersson FE. Oligomerization partially explains the lowering of Abeta42 in Alzheimer's disease cerebrospinal fluid. Neurodegener Dis 2009; 6: 139-47.
Lord A, Englund H, Söderberg L, Tucker S, Clausen F, Hillered L, Gordon M, Morgan D, Lannfelt L, Pettersson FE, Nilsson LN. Amyloid-beta protofibril levels correlate with spatial learning in Arctic Alzheimer's disease transgenic mice. Febs J 2009; 276: 995-1006.
Lord A, Gumucio A, Englund H, Sehlin D, Sundquist VS, Söderberg L, Möller C, Gellerfors P, Lannfelt L, Pettersson FE, Nilsson LN. An amyloid-beta protofibril-selective antibody prevents amyloid formation in a mouse model of Alzheimer's disease. Neurobiol Dis 2009; 36: 425-34.
Philipson O, Lannfelt L, Nilsson LN. Genetic and pharmacological evidence of intraneuronal Abeta accumulation in APP transgenic mice. FEBS Lett 2009; 583: 3021-6.
Näsström T, Wahlberg T, Karlsson M, Nikolajeff F, Lannfelt L, Ingelsson M, Bergström J. The lipid peroxidation metabolite 4-oxo-2-nonenal cross-links alpha-synuclein causing rapid formation of stable oligomers. Biochem Biophys Res Commun 2009; 378: 872-6.
Philipson O, Hammarström P, Nilsson KP, Portelius E, Olofsson T, Ingelsson M, Hyman BT, Blennow K, Lannfelt L, Kalimo H, Nilsson LN. A highly insoluble state of Abeta similar to that of Alzheimer's disease brain is found in Arctic APP transgenic mice. Neurobiol Aging 2009; 30: 1393-405
[Back]

2008

Sundelof J, Arnlov J, Ingelsson E, Sundstrom J, Basu S, Zethelius B, et al. Serum cystatin C and the risk of Alzheimer disease in elderly men. Neurology 2008 Sep 30;71(14):1072-9.
Basun H, Bogdanovic N, Ingelsson M, Almkvist O, Näslund J, Axelman K, Bird TD, Nochlin D, Schellenberg GD, Wahlund LO, Lannfelt L. Clinical and neuropathological features of the arctic APP gene mutation causing early-onset Alzheimer disease. Archives of neurology 2008; 65: 499-505.
Lannfelt L, Blennow K, Zetterberg H, Batsman S, Ames D, Harrison J, Masters CL, Targum S, Bush AI, Murdoch R, Wilson J, Ritchie CW. Safety, efficacy, and biomarker findings of PBT2 in targeting Abeta as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial. Lancet Neurol 2008; 7: 779-86.
Sundelöf J, Giedraitis V, Irizarry MC, Sundström J, Ingelsson E, Rönnemaa E, Ärnlöv J, Gunnarsson MD, Hyman BT, Basun H, Ingelsson M, Lannfelt L, Kilander L. Plasma beta amyloid and the risk of Alzheimer disease and dementia in elderly men: a prospective, population-based cohort study. Archives of neurology 2008; 65: 256-63.
[Back]

2007

Blennow K, Zetterberg H, Minthon L, Lannfelt L, Strid S, Annas P, Basun H, Andreasen N. Longitudinal stability of CSF biomarkers in Alzheimer's disease. Neurosci Lett 2007; 419: 18-22.
Englund H, Annerén G, Gustafsson J, Wester U, Wiltfang J, Lannfelt L, Blennow K, Höglund K. Increase in beta-amyloid levels in cerebrospinal fluid of children with Down syndrome. Dement Geriatr Cogn Disord 2007; 24: 369-74.
Englund H, Sehlin D, Johansson AS, Nilsson LN, Gellerfors P, Paulie S, Lannfelt L, Pettersson FE. Sensitive ELISA detection of amyloid-beta protofibrils in biological samples. Journal of neurochemistry 2007; 103: 334-45.
Giedraitis V, Sundelöf J, Irizarry MC, Gårevik N, Hyman BT, Wahlund LO, Ingelsson M, Lannfelt L. The normal equilibrium between CSF and plasma amyloid beta levels is disrupted in Alzheimer's disease. Neurosci Lett 2007; 427: 127-31.
Johansson AS, Bergquist J, Volbracht C, Päiviö A, Leist M, Lannfelt L, Westlind-Danielsson A. Attenuated amyloid-beta aggregation and neurotoxicity owing to methionine oxidation. Neuroreport 2007; 18: 559-63.
Johansson AS, Garlind A, Berglind-Dehlin F, Karlsson G, Edwards K, Gellerfors P, Ekholm-Pettersson F, Palmblad J, Lannfelt L. Docosahexaenoic acid stabilizes soluble amyloid-beta protofibrils and sustains amyloid-beta-induced neurotoxicity in vitro. Febs J 2007; 274: 990-1000.
Nilsson LN, Lannfelt L, Basun H, Nordberg A, Winblad B. Don't underestimate the value of transgenic animal models of Alzheimer disease. Lakartidningen 2007; 104: 798-9; discussion 9-800.
Sahlin C, Lord A, Magnusson K, Englund H, Almeida CG, Greengard P, Nyberg F, Gouras GK, Lannfelt L, Nilsson LN. The Arctic Alzheimer mutation favors intracellular amyloid-beta production by making amyloid precursor protein less available to alpha-secretase. Journal of neurochemistry 2007; 101: 854-62.
Sahlin C, Pettersson FE, Nilsson LN, Lannfelt L, Johansson AS. Docosahexaenoic acid stimulates non-amyloidogenic APP processing resulting in reduced Abeta levels in cellular models of Alzheimer's disease. The European journal of neuroscience 2007; 26: 882-9.
[Back]

Thematic research area Chronic Pain

2012

Nilsson E, Bodolea C, Gordh T, Larsson A. Cerebrospinal fluid cathepsin B and S. Neurol Sci. 2012 Mar 23. [Epub ahead of print]
[Back]

2011

Ohsawa M, Carlsson A, Asato M, Koizumi T, Nakanishi Y, Fransson R, et al. The dipeptide Phe-Phe amide attenuates signs of hyperalgesia, allodynia and nociception in diabetic mice using a mechanism involving the sigma receptor system. J. Mol Pain. 2011, 31;7(1):85.
Zhou Q, Carlsson A, Hallberg M, Nyberg F. Substance P N-terminal fragment SP(1-7) attenuates chronic morphine tolerance and affects dynorphin B and nociceptin in rats. Peptides. 2011;32(8):1661-1665.
Kalliomäki M, Kieseritzky JV, Schmidt R, Hägglöf B, Karlsten R, Sjögren N, Albrecht P, Gee L, Rice F, Wiig M, Schmelz M, Gordh T. Structural and functional differences between neuropathy with and without pain? Exp Neurol. 2011 Oct;231(2):199-206.
Linnman C, Appel L, Fredrikson M, Gordh T, Söderlund A, Långström B, Engler H. Elevated [11C]-D-deprenyl uptake in chronic Whiplash Associated Disorder suggests persistent musculoskeletal inflammation. PLoS One. 2011 Apr 19;6(4):e19182.
Thorsell J, Finnes A, Dahl J, Lundgren T, Gybrant M, Gordh T, Buhrman M. A comparative study of 2 manual-based self-help interventions, acceptance and commitment therapy and applied relaxation, for persons with chronic pain. Clin J Pain. 2011 Oct;27(8):716-23.
Pontén E, Fredriksson A, Gordh T, Eriksson P, Viberg H. Neonatal exposure to propofol affects BDNF but not CaMKII, GAP-43, synaptophysin and tau in the neonatal brain and causes an altered behavioural response to diazepam in the adult mouse brain. Behav Brain Res. 2011 Sep 30;223(1):75-80.
Wadensten B, Fröjd C, Swenne CL, Gordh T, Gunningberg L. Why is pain still not being assessed adequately? Results of a pain prevalence study in a university hospital in Sweden. J Clin Nurs. 2011 Mar;20(5-6):624-34.
[Back]

2010

Opioid endocrinopathy: a clinical problem in patients with chronic pain and long-term oral opioid treatment. Rhodin A, Stridsberg M, Gordh T. Clin J Pain. 2010 Jun;26(5):374-80.
Reporting of trials of gabapentin. Gordh TE, Jensen TS, Kalso E. N Engl J Med. 2010 Apr 29;362(17):1641; author reply 1641-2.
Ventromedial prefrontal neurokinin 1 receptor availability is reduced in chronic pain. Linnman C, Appel L, Furmark T, Söderlund A, Gordh T, Långström B, Fredrikson M. Pain. 2010 Apr;149(1):64-70. Epub 2010 Feb 4.
Testing whether the epidural works: too time consuming? Larsson J, Gordh TE. Acta Anaesthesiol Scand. 2009 Dec 21. [Epub ahead of print] In print Jan 2010
Natural course of long-term postherniorrhaphy pain in a population-based cohort. Gabriel Sandblom, Maija-Liisa Kalliomäki, Ulf Gunnarsson, Torsten Gordh Scandinavian Journal of Pain, Volume 1, Issue 1, January 2010, Pages 55-59
Important knowledge of pain and phantom experiences after breast surgery and leg- or arm-amputation: Value of qualitative pain research. Stephen Butler, Torsten Gordh. Scandinavian Journal of Pain, Volume 1, Issue 1, January 2010, Page 8
[Back]

2009

Nitric oxide and pain: ”Something old, something new”. Miclescu A, Gordh T. Acta Anaesthesiol Scand. 2009 Oct;53(9):1107-20. Epub 2009 Aug 21. Review.PMID: 19702699.
The C-terminal amidated analogue of the substance P (SP) fragment SP(1-7) attenuates the expression of naloxone-precipitated withdrawal in morphine dependent rats. Zhou Q, Carlsson A, Botros M, Fransson R, Sandström A, Gordh T, Hallberg M, Nyberg F. Peptides. 2009 Dec;30(12):2418-22. Epub 2009 Aug 15.PMID: 19686790.
A quantitative peptidomic analysis of peptides related to the endogenous opioid and tachykinin systems in nucleus accumbens of rats following naloxone-precipitated morphine withdrawal. Rossbach U, Nilsson A, Fälth M, Kultima K, Zhou Q, Hallberg M, Gordh T, Andren PE, Nyberg F. J Proteome Res. 2009 Feb;8(2):1091-8.PMID: 19159213.
Research on Genes predisposing for chronic pain: a challenge for pain researchers in Scandinavia. Lind AL, Gordh TE. Scandinavian Journal of Pain 2009, 1; s1, 24-26.
Chronic whiplash symptoms are related to altered regional cerebral blood flow in the resting state. Linnman C, Appel L, Söderlund A, Frans O, Engler H, Furmark T, Gordh T, Långström B, Fredrikson M. Eur J Pain. 2009 Jan;13(1):65-70. Epub 2008 May 16.PMID: 18486506.
Persistent pain after groin hernia surgery: a qualitative analysis of pain and its consequences for quality of life. Kalliomäki ML, Sandblom G, Gunnarsson U, Gordh T. Acta Anaesthesiol Scand. 2009 Feb;53(2):236-46. Epub 2008 Dec 15.PMID: 19094175.
[Back]

2008

Neonatal ketamine exposure results in changes in biochemical substrates of neuronal growth and synaptogenesis, and alters adult behavior irreversibly. Viberg H, Pontén E, Eriksson P, Gordh T, Fredriksson A. Toxicology. 2008 Jul 30;249(2-3):153-9. Epub 2008 May 4.PMID: 18550250.
[Back]

Thematic research area Explorative Research and Technology development

2012

G. Shevchenko, S. Musunuri, M. Wetterhall, J. Bergquist. Comparison of extraction methods for the comprehensive analysis of mouse brain proteome using shotgun based mass spectrometry. J. Proteome Res. 2012.
Dahlin AP, Hjort K, Hillered L, Sjödin MOD, Bergquist J and Wetterhall M (2012). Multiplexed quantification of proteins adsorbed to surface-modified and non-modified microdialysis membranes. Anal Bioanal Chem. Volume 402, Number 6, 2057-2067.
[Back]

2011

S. Darmanis, R. Y. Nong, J. Vänelid, A. Siegbahn, O. Ericsson, S. Fredriksson, C. Bäcklin, M. Gut, S. Heath, I. G.Gut, L. Wallentin, M. G. Gustafsson, M. Kamali-Moghaddam and U. Landegren. (2011). ProteinSeq: high-performance protein biomarker analysis via proximity ligation with next generation sequencing in cardiovascular disease. PLoS one, 6:e25583s.
Högberg N; Carlsson P-O; Hillered L; Meurling S; Stenbäck A (2011) Intestinal ischemia measured by intraluminal microdialysis. Scand J Clin Lab Invest.
Slósarczyk, A. T., Ramapanicker, R., Norberg, T., and Baltzer, L: Mixed pentafluorophenyl and o-fluorophenyl esters of aliphatic dicarboxylic acids: efficient tools for peptide and protein conjugation. RSC Advances, (2011).
Elhamili A., Samuelsson J., Bergquist J., Wetterhall M. Optimizing the extraction, separation and quantification of tricyclic antidepressant drugs in human plasma with CE-ESI-TOF-MS using cationic coated capillaries Electrophoresis 32(6-7) 647-658 (2011)
Wetterhall M., Shevchenko G., Artemenko K., Sjödin M., Bergquist J., Analysis of Membrane and Hydrophilic Proteins Simultaneously Derived from the Mouse Brain Using Cloud-Point Extraction Analytical and Bioanalytical Chemistry 400(9) 2827-2836 (2011)
Yanling Liu, Jijuan Gu, Åsa Hagner-McWhirter, Poojahrau Sathiyanarayanan, Mats Gullberg, Ola Söderberg, Johan Johansson, Maria Hammond, Daniel Ivansson, and Ulf Landegren. Western Blotting via Proximity Ligation for High Performance Protein Analysis Mol Cell Proteomics 2011 10: O111.011031. First Published on August 2, 2011.
Tegler LT, Nonglaton G, Büttner F, Caldwell K, Christopeit T, Danielson UH, Fromell K, Gossas T, Larsson A, Longati P, Norberg T, Ramapanicker R, Rydberg J, Baltzer L. Powerful Protein Binders from Designed Polypeptides and Small Organic Molecules-A General Concept for Protein Recognition. Angew Chem Int Ed Engl. 2011 Feb 18;50(8):1823-7. IF 11.83
Åkerfeldt T, Larsson A. Postsurgical inflammation is associated with increased cathepsin B and decreased cathepsin S concentrations in the circulation. Scand J Clin Lab Invest. 2011 May;71(3):203-7. IF 1.39
Larsson A, Hansson L-O, Flodin M, Katz R, Shlipak M. Calibration of the Siemens cystatin C immunoassay has changed over time. Clin Chem. 2011 May;57(5):777-8. IF 6.26.
Tavoosidana G, Ronquist G, Darmanis S, Carlsson L, Wu D, Conze T, Ek P, Semjonow A, Eltze E, Larsson A, Landegren U, Kamali-Moghaddam M. Prostasomes assessed in human blood plasma are biomarkers predicting Gleason score in prostatectomy specimens. Proc Natl Acad Sci U S A. 2011 May 24;108(21):8809-14. IF 10.3
[Back]

2010

Mining ventricular cerebrospinal fluid from patients with traumatic brain injury using hexapeptide ligand libraries to search for trauma biomarkers. Marcus O.D. Sjödin, Jonas Bergquist, Magnus Wetterhall. Journal of Chromatography B 2010 878 (22):2003-2012.
Cloud-Point Extraction and Delipidation of Porcine Brain Proteins in Combination with Bottom-Up Mass Spectrometry Approaches for Proteome Analysis. Ganna Shevchenko, Marcus O. D. Sjödin, David Malmström, Magnus Wetterhall, Jonas Bergquist. Journal of Proteome Research. Article ASAP (Publication on Web: June 30, 2010).
Methodological Aspects on Microdialysis Protein Sampling and Quantification in Biological Fluids: An In Vitro Study on Human Ventricular CSF. Andreas P. Dahlin, Magnus Wetterhall, Karin D. Caldwell, Anders Larsson, Jonas Bergquist, Lars Hillered, Klas Hjort. Analytical Chemistry 2010 82 (11), 4376-4385
Degerman Gunnarsson M, Lindau M, Wall A, Blennow K, Darreh-Shori T, Basu S, Nordberg A, Larsson A, Lannfelt L, Basun H, Kilander L. Pittsburgh compound-B and Alzheimer's disease biomarkers in CSF, plasma and urine: An exploratory study. Dement Geriatr Cogn Disord. 2010;29(3):204-12.
Lipcsey M, Olovsson M, Larsson E, Einarsson R, Qadhr GA, Sjölin J, Larsson A. The brain is a source of S100B increase during endotoxemia in the pig. Anesth Analg. 2010 Jan;110(1):174-80.
Albrecht, C., Fechner, P., Honcharenko, D., Baltzer, L., Gauglitz, G: "A new assay design for clinical diagnostics based on alternative recognition elements", Biosensors and Bioelectronics 25 (2010) 2302-2308.
Zhang, Q., Norberg, T., Bergquist, J., Baltzer, L. : "Synthesis of C-11 linked active ester derivatives of vitamin D3 and their conjugations to 42-residue helix loop helix peptides", Tetrahedron 66 (2010) 4577-4586.
Assessment of the partitioning capacity of high abundant proteins in human cerebrospinal fluid using affinity and immunoaffinity subtraction spin columns. Wetterhall M, Zuberovic A, Hanrieder J, Bergquist J. Journal of Chromatography B, 2010 878: 1519–1530.
Analysis of peptides using N-methylpolyvinylpyridium as silica surface modifier for CE-ESI-MS. Elhamili A, Wetterhall M, Sjödin M, Sebastiano R, Bergquist J. Electrophoresis. 2010 Apr;31(7):1151-6.
[Back]

2009

Said Ahmed D, Larsson A, Hillered L, Wande B, Ryden I. Quantitative determination of cerebrospinal fluid bilirubin on a high throughput chemistry analyzer. Clinical Laboratory. 2009;55(7-8):283-288.
Larsson A, Hillered L, Ridefelt P. Analys av csv-hemoglobin och –bilirubin. Klinisk Biokemi i Norden. 2009;3:29-33.
Hanrieder J., Wetterhall M., Enblad P., Hillered L., Bergquist J., Temporally Resolved Differential Proteomic Analysis of Human Ventricular CSF for Monitoring Traumatic Brain Injury Biomarker Candidates J Neurosci. Methods, 177(2) 469-478 (2009).
Zuberovic A., Wetterhall M., Hanrieder J., Bergquist J. CE MALDI-TOF/TOF MS for Multiplexed Quantification of Proteins in Human Ventricular CSF Electrophoresis 30(10) 1836-1843 (2009)
[Back]

2008

Hansson LO, Flodin M, Nilsen T, Caldwell K, Fromell K, Sunde K, et al. Comparison between chicken and rabbit antibody based particle enhanced cystatin C reagents for immunoturbidimetry. J Immunoassay Immunochem 2008;29(1):1-9.
Zuberovic A., Hanrieder J., Bergquist J., Wetterhall M., Proteome Profiling of Human CSF: Exploring the potential of capillary electrophoresis with surface modified capillaries for analysis of complex biological samples Eur. J. Mass Spectrom. 14(4) 249–260 (2008)
[Back]

2007

SM. Gustafsdotti, J. Schlingemann, A. Rada-Iglesias, E. Schallmeiner, M. Kamali-Moghaddam, C. Wadelius & U. Landegren. (2007). In vitro analysis of DNA-protein interactions by proximity ligation. PNAS, 104: 3067-72.
Darmanis S., Kähler A., Spångberg L., Kamali-Moghaddam M, Landegren U. and Schallmeiner E. (2007). Self-assembly of proximity probes for the use in flexible and modular proximity ligation assay. Biotechniques. 43:443-4.
[Back]

PARTNERS
Uppsala Berzelii Technology Centre for Neurodiagnostics | Email info@berzelii.uu.se